Adm1n at 11:38, 14 April 2015

2015-04-14T11:38:31Z

Adm1n: Created page with "'''JWH-203''' (1-pentyl-3-(2-chlorophenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist with approximately e..."

2015-02-15T02:12:33Z

Created page with "'''JWH-203''' (1-pentyl-3-(2-chlorophenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist with approximately e..."

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'''JWH-203''' (1-pentyl-3-(2-chlorophenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a [[cannabinoid]] agonist with approximately equal affinity at both the [[CB1]] and [[CB2]] receptors, having a Ki of 8.0nM at CB1 and 7.0nM at CB2. It was originally discovered by, and named after, Dr. John W. Huffman, but has subsequently been sold without his permission as an ingredient of synthetic cannabis smoking blends. Similar to the related 2'-methoxy compound [[JWH-250]], the 2'-bromo compound JWH-249, and the 2'-methyl compound [[JWH-251]], JWH-203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds, and has the strongest in vitro binding affinity for the [[cannabinoid receptors]] of any compound in the phenylacetyl group.

Unexpectedly despite its weaker CB1 Ki in vitro, the 2-methylindole derivative [[JWH-204]] is actually more potent than JWH-203 in animal tests for cannabinoid activity, though it is still weaker than [[JWH-249]].

==See also==

* [[N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide]]

← Older revision		Revision as of 11:38, 14 April 2015
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−	'''JWH-203''' (1-pentyl-3-(2-chlorophenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a [[cannabinoid]] agonist with approximately equal affinity at both the [[CB1]] and [[CB2]] receptors, having a Ki of 8.0nM at CB1 and 7.0nM at CB2. It was originally discovered by, and named after, Dr. John W. Huffman, but has subsequently been sold without his permission as an ingredient of synthetic cannabis smoking blends. Similar to the related 2'-methoxy compound [[JWH-250]], the 2'-bromo compound JWH-249, and the 2'-methyl compound [[JWH-251]], JWH-203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds, and has the strongest in vitro binding affinity for the [[cannabinoid receptors]] of any compound in the phenylacetyl group.	+	'''JWH-203''' (1-pentyl-3-(2-chlorophenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a [[cannabinoid]] agonist with approximately equal affinity at both the [[CB1]] and [[CB2]] receptors, having a Ki of 8.0nM at CB1 and 7.0nM at CB2. It was originally discovered by, and named after, Dr. John W. Huffman, but has subsequently been sold without his permission as an ingredient of [[synthetic cannabis]] smoking blends. Similar to the related 2'-methoxy compound [[JWH-250]], the 2'-bromo compound [[JWH-249]], and the 2'-methyl compound [[JWH-251]], [[JWH-203]] has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds, and has the strongest in vitro binding affinity for the cannabinoid receptors of any compound in the phenylacetyl group.

−	Unexpectedly despite its weaker CB1 Ki in vitro, the 2-methylindole derivative [[JWH-204]] is actually more potent than JWH-203 in animal tests for cannabinoid activity, though it is still weaker than [[JWH-249]].	+	Unexpectedly despite its weaker CB1 Ki in vitro, the 2-methylindole derivative JWH-204 is actually more potent than JWH-203 in animal tests for cannabinoid activity, though it is still weaker than [[JWH-249]].

JWH-203 - Revision history

Adm1n at 11:38, 14 April 2015

Adm1n: Created page with "'''JWH-203''' (1-pentyl-3-(2-chlorophenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist with approximately e..."