View source for WIN 55,212-2

WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of [[cannabinoids]] such as [[tetrahydrocannabinol]] (THC) but has an entirely different chemical structure.


WIN 55,212-2 is a potent cannabinoid receptor agonist that has been found to be a potent analgesic in a rat model of neuropathic pain. It activates p42 and p44 MAP kinase via receptor-mediated signaling.


At 5 µM WIN 55,212-2 inhibit ATP production in sperm in a [[CB1]] receptor-dependent fashion.


WIN 55,212-2, along with HU-210 and JWH-133, may prevent the inflammation caused by amyloid beta proteins involved in Alzheimer's disease, in addition to preventing cognitive impairment and loss of neuronal markers. This anti-inflammatory action is induced through agonist action at [[cannabinoid receptors]], which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglial activation in rat models.


WIN 55,212-2 is a full agonist at the CB1 cannabinoid receptor (Ki = 1.9 nM) and has much higher affinity than THC (Ki = 41 nM) for this receptor.

WIN 55,212-2 reduces voluntary wheel running in laboratory mice, but with effects that depend on both genetic background and sex.

==See also==
* [[WIN 48,098]]
* [[WIN 54,461]]
* [[WIN 55,225]]
* [[WIN 56,098]]